Antidepressant activity of buspirone in anxiety
β Scribed by B.J.C. Allmann; A. Domantay; H.S. Schoeman
- Book ID
- 117090567
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 361 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0011-393X
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π SIMILAR VOLUMES
In this study buspirone demonstrated efficacy and safety in the treatment of anxiety in elderly patients age 80 years or older. The results are consistent with data from earlier clinical and pharmacokinetic studies in elderly patients 60 years and older.
The anxiolytic, buspirone, was given to rats in combination with four antidepressants: clomipramine (3-30mg/g), desipramine (5-10mg/ kg), maprotiline (5-15 mg/ kg) and mianserin (10-15mg/ kg). Even 2 mg/ kg buspirone caused a significant incidence of myoclonic seizures, when combined with clomiprami