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Antidepressant activity of alprazolam in a reserpine-induced model of depression

✍ Scribed by M.D.; Ph.D. Vimala H. Sethy; Donald H. Hodges Jr.

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 293 KB
Volume: 5
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.430050211

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of chronic (14-21 day) administration of reserpine (0.1 rnglkglday), imipramine (10 mglkglday), alprazolam (5, 10 and 15 rnglkglday), and diazepam (10 and 30 mglkgl day) on beta-adrenergic receptors in the cerebral cortex and body weight has been reported in this study. Chronic treatment with both imipramine and alprazolam significantly blocked reserpine-induced increases in beta-adrenergic receptors and loss in body weight. However, diazepam under similar conditions had no significant effect.

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