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Anticonvulsant Efficacy of Topiramate in Phenytoin-Resistant Kindled Rats

✍ Scribed by Elke Reissmüller; Ulrich Ebert; Wolfgang Löscher

Book ID
109107146
Publisher
Wiley (Blackwell Publishing)
Year
2000
Tongue
English
Weight
768 KB
Volume
41
Category
Article
ISSN
0013-9580

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Topiramate: a potent anticonvulsant in the amygdala-kindled rat
✍ Albert Wauquier; Shangdan Zhou 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 388 KB

Topiramate, a chemically novel anti-epileptic drug, was evaluated in amygdala-kindled seizures in rats. Topiramate, given at doses between 0.63 and 80 mg/kg i.p. and p.o. 4 h before kindling stimulation, exhibited a dose-related inhibition on all seizure parameters measured, i.e. behavioral seizures