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Anticonvulsant effects of melatonin in amygdala-kindled rats

✍ Scribed by Meike Mevissen; Ulrich Ebert

Book ID
117477171
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
301 KB
Volume
257
Category
Article
ISSN
0304-3940

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Topiramate, a chemically novel anti-epileptic drug, was evaluated in amygdala-kindled seizures in rats. Topiramate, given at doses between 0.63 and 80 mg/kg i.p. and p.o. 4 h before kindling stimulation, exhibited a dose-related inhibition on all seizure parameters measured, i.e. behavioral seizures