Anticonvulsant activity of a new 1,4-benzodiazepine in rodents and the baboon Papio papio

✍ Scribed by David C. Piper; B. S. Meldrum; C. R. Gardner

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 283 KB
• Volume: 1
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430010110

✦ Synopsis

Abstract

RU 31124, a new anticonvulsant 1,4‐benzodiazepine was compared with clonazepam in a series of tests in rats and mice. It demonstrated greater anticonvulsant potency whilst having equivalent sedative properties to clonazepam. This profile of activity was confirmed in the photosensitive baboon, Papio papio, in which RU 31124 provided long‐lasting protection against convulsions at doses having little or no sedative side effects.