Anticonvulsant Action of Withania somnifera (Aswaganda) Root Extract against Pentylenetetrazol-induced Kindling in Mice

✍ Scribed by S. K. Kulkarni; B. George

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 209 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199608)10:5<447::aid-ptr869>3.0.co;2-m

✦ Synopsis

Repeated administration of pentylenetetrazol (PTZ, 30 mglkg, thrice a week for 9 weeks) produced chemical kindling when mice were challenged with a subconvulsive dose of the convulsant. These animals were also found to be susceptible to seizures after a subconvulsant dose of a beta-carboline, (FG 7142, 20mglkg). Withunk sornniferu root extract (100 mglkg) offered a significant protection against PTZ-induced chemical kindling, and the effect was comparable to diazepam (1 mglkg). The protective effect of W. wornniferu appears to involve GABAergic mediation.