𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Anticollagen antibodies and immune response gene products in rheumatoid arthritis

✍ Scribed by David H. Collier; S. S. Kerwar; Marvin R. Garovoy; Kenneth H. Fye; John D. Stobo

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
781 KB
Volume
27
Category
Article
ISSN
0004-3591

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✦ Synopsis

Circulating antibodies to native and denatured types I and I1 human and bovine collagens were assayed in patients with rheumatoid arthritis (RA), patients with other rheumatic diseases, and normal individuals. A subgroup of this population was also assayed for reactivity with typing reagents which detect determinants (MT and HLA-DR) present in human immune response gene products. The mean titers of antibodies to each collagen tested were not significantly higher in RA patients when compared with patients who had other rheumatic diseases. Although both MT3 and MT4 were significantly associated with RA, there was no significant association between the anticollagen antibodies and any MT type or HLA-DR4. These studies raise a question concerning From the

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