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Anticoagulant activity of a synthetic heparinoid in relation to molecular weight andN-sulfate content

✍ Scribed by Sederel, L. C. ;van Der Does, L. ;van Duijl, J. F. ;Beugeling, T. ;Bantjes, A.

Book ID: 102293406
Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 437 KB
Volume: 15
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820150606

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✦ Synopsis

Abstract

Addition of chlorosulfonyl isocyanate to CC bonds in cis‐1,4‐polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water‐soluble polyelectrolyte with N‐sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N‐sulfate content.

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