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Anticancer Multidrug Resistance Mediated by MRP1: Recent Advances in the Discovery of Reversal Agents

✍ Scribed by Abcene Boumendjel; Helene Baubichon-Cortay; Doriane Trompier; Thomas Perrotton; Attilio Di Pietro


Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract Multidrug resistance protein 1 (MRP1) belongs to the ATP‐binding cassette (ABC) transporter family. It is able to transport a broad range of anticancer drugs through cellular membranes, thus limiting their antiproliferative action. Since its discovery in 1992, MRP1 has been the most stu

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