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Anticancer agent development: X-ray crystal structure and keto-enol tautomerism of dimethyl 1-hydroxy-6,7-methylenedioxy-4-(3′,4′,5′-trimethoxyphenyl-trans-3,4-dihydronaphthalene-2,3-dicarboxylate

✍ Scribed by John R. Peterson; Tamara J. Winter; Hoang D. Do; Robin D. Rogers


Publisher
Springer
Year
1989
Tongue
English
Weight
595 KB
Volume
19
Category
Article
ISSN
1572-8854

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Synthesis and X-ray crystal structure of
✍ Robert B. Palmer; Niels H. Andersen 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 242 KB

We report the synthesis and X-ray crystal structure of 1,4-dihydro-2,6-dimethyl-4-(2'isopropylphenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester (4), an analogue of the 1,4dihydropyridine calcium channel antagonist, nifedipine. Solution state NOE data indicate the presence of both rotameric forms