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Antibody valence and induced signal transduction: The role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells

✍ Scribed by Larry B. Melton; Fadi Lakkis; Miriam Moscovitch-Lopatin; Brian R. Smith; John M. Williams; Philip M. Rosoff; Terry B. Strom


Book ID
118375094
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
801 KB
Volume
50
Category
Article
ISSN
1090-2341

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Monoclonal antibodies (mAb) directed against the T cell differentiation antigen CD28 (Tp44) induce proliferation of resting T lymphocytes in the presence of phorbol esters. Moreover, it has been reported that such antibodies augment and sustain T cell proliferation induced by soluble antigens, phyto