Antibody structure and the evolution of immunoglobulin V gene segments
β Scribed by Perry M. Kirkham; Harry W. Schroeder Jr
- Book ID
- 115647776
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 837 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1044-5323
No coin nor oath required. For personal study only.
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## Abstract Sequencing of all human immunoglobulin (Ig) germline gene segments has recently been completed. However, our first glimpses of the recombined products of this combinatorial gene system were in the 1970s, in landmark publications, reporting the crystal structures of two human myeloma pro
The carboxyterminal region of the heavy chains, according to its hydrophilic or hydrophobic properties, determines whether the immunoglobulin will be secreted or membrane-bound. We have determined the nucleotide sequences of the human IGHG3, IGHA1, and IGHA2 membrane exons isolated from genomic DNA