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Antibody responses in normal infants and in infants receiving chemotherapy for congenital neuroblastoma

✍ Scribed by H. Alice Orgel; Robert N. Hamburger; Louis M. Mendelson; J. Randall Miller; Faith H. Kung


Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
265 KB
Volume
40
Category
Article
ISSN
0008-543X

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✦ Synopsis


Three infants with congenital neuroblastoma received a primary series of diptheria-pertassis-tetanus (DPT) immunizations during and after courses of chemotherapy with immunosuppressive medications. Serum IgG, IgA and IgM levels and antidiphtheria and antitetanus antibody responses were measured and compared with those of normal infants of similar age. Protective levels of antibody were achieved by the study patients as well as by the control group. These results support the view that children with malignancies who are receiving chemotherapy should not be denied immunization with inactivated vaccines.


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