Antibody responses in normal infants and in infants receiving chemotherapy for congenital neuroblastoma
β Scribed by H. Alice Orgel; Robert N. Hamburger; Louis M. Mendelson; J. Randall Miller; Faith H. Kung
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 265 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
Three infants with congenital neuroblastoma received a primary series of diptheria-pertassis-tetanus (DPT) immunizations during and after courses of chemotherapy with immunosuppressive medications. Serum IgG, IgA and IgM levels and antidiphtheria and antitetanus antibody responses were measured and compared with those of normal infants of similar age. Protective levels of antibody were achieved by the study patients as well as by the control group. These results support the view that children with malignancies who are receiving chemotherapy should not be denied immunization with inactivated vaccines.
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Background. Mass population screening of infants for neuroblastoma was introduced in Japan in 1985. Other investigations of screening have been carried out in North America and Europe. Procedure. This paper summarizes the epidemiological results from the reports published from the infant screening p