Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

✍ Scribed by Linqi Zhang; Fengwen Zhang; Wenjie Yu; Tian He; Jian Yu; Christopher E. Yi; Lei Ba; Wenhui Li; Michael Farzan; Zhiwei Chen; Kwok-Yung Yuen; David Ho

• Book ID: 102379645
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 341 KB
• Volume: 78
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.20499

✦ Synopsis

Abstract

Most of the SARS‐CoV‐infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein‐specific and S glycoprotein‐specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS‐CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein‐specific and S glycoprotein‐specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS‐CoV‐infected patients. J. Med. Virol. 78:1–8, 2006. © 2005 Wiley‐Liss, inc.