Antibody response to inactivated polio vaccine (E-IPV) in children born to HIV positive mothers

✍ Scribed by M. Barbi; M. Bardare; C. Luraschi; G. Zehender; M. Clerici Schoeller; G. Ferraris

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 464 KB
• Volume: 8
• Category: Article
• ISSN: 0393-2990
• DOI: 10.1007/bf00144802

✦ Synopsis

In order to evaluate the response to immunization of HIV-infected children we studied the humoral response to an enhanced potency inactivated poliovaccine (E-IPV) of 43 children born of H1V seropositive mothers. All these subjects have been followed for 32 (15-48) months in order to ascertain their infection status.

After a course of 2 doses of E-IPV, 88% of children had neutralizing antibody (n.a.) titers > 1:4 to the 3 poliovirus serotypes and 100% to at least 2 polio strains. No statistically significant differences both as rates of n.a. positive subjects and as antibody levels were found between H1V infected children and those who lost HIV antibodies. The poorest response was observed in subjects with full-blown immunodeficiency (CD4 < 1000/mm 3, reduced response to PWM).

Sixteen children also received a booster dose of vaccine one year after the completion of the primary cycle. Infected and non-infected subjects responded to the same extent with high levels of n.a. to this immunization. Interestingly, the recall dose was also able to induce high n.a. titers in those HIV infected children who showed significant decreases of n.a. titers in the months following the end of the primary cycle.