## Abstract Gangliosides expressed in malignant melanoma are potential targets for immunotherapy. Immunization of melanoma patients with vaccines containing purified GM2 ganglioside has resulted in induction of GM2 antibodies, and high titers of GM2 antibodies have correlated with increased surviva
Antibody response to immunization with ganglioside GD3 and GD3 congeners (lactones, amide and gangliosidol) in patients with malignant melanoma
โ Scribed by Gerd Ritter; Erika Boosfeld; Rita Adluri; Michele Calves; Herbert F. Oettgen; Lloyd J. Old; Philip Livingston
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 786 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0020-7136
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๐ SIMILAR VOLUMES
The gangliosides GD3, GD2 and GM2 are expressed on the cell surface of malignant melanomas, GD3 being the most abundant. We have shown that immunization of melanoma patients with GM2 adherent to Bacillus Calmette-Guerin (GM2/BCG) induced an IgM antibody response. Vaccines containing GM2-keyhole limp
## BACKGROUND. Antitumor effects of antibodies against ganglioside antigens of melanoma have been reported, but neither optimal doses nor mechanisms have been established. ## METHODS. This Phase IB trial of the murine immunoglobulin IgG 3 monoclonal antibody R 24 against disialoganglioside GD3