Antibody response to adenovirus Elb-derived synthetic peptides and serum levels of p53 in patients with gastrointestinal and other malignant lymphomas
✍ Scribed by Dr. M.-L. Lähdeaho; T. Lehtinen; R. Aine; T. Hakala; M. Lehtinen
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 364 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Serum levels of p53 and antipeptide antibody levels to adenovirus type 12 (Ad12) E1b protein were measured in a case‐control study of 62 newly diagnosed patients with malignant lym‐phoma. While patients with gastrointestinal lym‐phoma did not differ from their matched controls, p53 positive lymphoma patients had significantly (P < 0.04) increased antipeptide IgG antibody levels to the Ad12 E1b. Concomitant detection of serum p53 and antipeptide antibodies to Ad 12 E1b was associated with an increased risk (OR = 17.0, 95% confidence limits 1.5, 58.5) of malignant lymphoma suggesting synergism between expression of Ad12 Elb and accumulation of p53 in patients with malignant lymphoma. © 1994 Wiley‐Liss, Inc.