Antibody response after application of a new live attenuated mumps vaccine (Pariorix®) measured by enzyme-linked immunosorbent assay (ELISA)
✍ Scribed by Therese Popow-Kraupp; Christian Kunz; Hanns Hofmann
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 594 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Mumps virus specific antibody concentrations were determined by enzyme‐linked immunosorbent assay (ELISA), hemolysis‐in‐gel (HIG) test, and hemagglutination‐inhibition (HI) test in 17 adult volunteers before and after vaccination with a new live mumps vaccine, Pariorix®. The results of the present study indicate that the strain Urabe‐Am 9 of the mumps virus (Pariorix) induces antibodies in 100% of seronegative adults when measured by ELISA and in 70.6% and 64.7% in HIG and HI, respectively. ELISA is therefore a very sensitive and reliable method for the demonstration of sero‐conversion after vaccination. The vaccine was well tolerated and clinically acceptable in the group of adult volunteers.