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Antibody guided enzyme activation of amygdalin

✍ Scribed by Millinger, Susan P.


Book ID
122020156
Publisher
Elsevier Science
Year
1990
Weight
144 KB
Volume
26
Category
Article
ISSN
0277-5379

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We describe a novel version of antibody-directed enzyme prodrug therapy (ADEPT), with the use of amygdalin as prodrug. Amygdalin is a naturally occurring cyanogenic glycoside, which can be cleaved by sweet almond ␀-glucosidase to yield free cyanide. If amygdalin could be activated specifically at th