Antibody-guided diagnosis: An italian experience on cea-expressing tumours
✍ Scribed by Pietro Riva; G. Moscatelli; G. Paganelli; S. Benini; Antonio Siccardi
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 667 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Within the Italian CNR Biomedical Technology programmes a large multicentre clinical trial on CEA-expressing carcinomas has been carried out. F(ab')z fragments of anti-CEA monoclonal antibody (MAb) F023C5, radiolabelled with either I3'l or "'In, were supplied t o 10 different Italian nuclear medicine departments. Over 500 patients with gastrointestinal, lung, breast, and other carcinomas have been investigated. The results obtained in our nuclear medicine department are reported here.
In GI cancer group, the '"1 compound showed better results except in liver metastases detected only in 28/57 patients. In the lung cancer roup, very satisfactory results were achieved in primary tumours and local or systemic recurrences: "'ln tracer was preferentially used. In the breast cancer group immunoscintigraphy proved t o be helpful in differential diagnosis of neoplastic and benign bone lesions. Significant improvements of diagnostic sensitivity were achieved in GI cancer patients by means of i.p. administration. Finally, I2 patients with advanced disease were given different l 3 I l radioiodinated MAbs (100 mCi average dose). Administration route was either i.v. (3 cases) or i.p. (9 cases). Clinical and instrumental evidence of complete (I) or partial (7) response was observed i n 8 patients.