Antibody-directed therapy of multidrug-resistant tumor cells
โ Scribed by Thomas Efferth; Manfred Volm
- Book ID
- 112963961
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 793 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1357-0560
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๐ SIMILAR VOLUMES
## We describe the lysis of multidrug-resistant (MDR) tumor cells by various lymphocytic effector cells, retargeted with bispecific antibodies (heteroconjugates). The Ab -heteroconjugate used was prepared by chemically cross-linking the OKT3 monoclonal antibody (MAb) reactive with CD3 antigen on T
The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATPdriven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro