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Antibody-Directed Effector Cell Therapy of Tumors: Analysis and Optimization Using a Physiologically Based Pharmacokinetic Model

✍ Scribed by Friedrich, Stuart W.; Linz, Stephany C.; Stoll, Brian R.; Baxter, Laurence T.; Munn, Lance L.; Jain, Rakesh K.

Book ID: 122280863
Publisher: Neoplasia Press
Year: 2002
Tongue: English
Weight: 249 KB
Volume: 4
Category: Article
ISSN: 1522-8002
DOI: 10.1038/sj.neo.7900260

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## Abstract Three monoclonal antibodies (MAbs), MOv17, MOv 18 and MOv19 with tumor‐restricted specificity for human ovarian carcinoma, were tested alone or in double combination with the aim of analyzing their binding and internalization behavior on different __In vitro__ cell lines. Biochemical st