Antibody-dependent cellular cytotoxicity (ADCC) in colorectal carcinoma. I. Favorable prognosis in female patients

✍ Scribed by E. Pihl; R. C. Nairn; A. P. P. Nind; S. L. Jones; P. J. Chalmers; G. R. Pullen; E. S. R. Hughes; A. M. Cuthbertson

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 352 KB
• Volume: 24
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930240318

✦ Synopsis

In an immunological study of 288 colorectal carcinoma patients. wc investigated the relationship between survival and prcopcrative in vitro antibody-dcpendent cellular cytotoxicity (ADCC) against thc colonic carcinoma cell line HT-29. A highly significantly favorable (p = 0.001) association was found in thc: 20 female patients with ADCC. Nearly all (97%) of the 66 paticnts with ADCC wcre blood group 0, but blood group per se did not relate to survival. nor could staging explain the survival association with ADCC. The mechanism whcreby ADCC or its in vivo expression confers a survival advantage is unknown but we suggcst that it derives from immunoreactivity against blood group A antigens produced inappropriately in the carcinomatous epithelium of thc group 0 and B patients.

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