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Antibody-dependent cell-mediated cytotoxicity in treated and nontreated cancer patients

✍ Scribed by M. L. Stratton; J. Herz; R. A. Loeffler; F. L. McClurg; A. Reiter; P. Bernstein; D. L. Danley; E. Benjamini

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
575 KB
Volume
40
Category
Article
ISSN
0008-543X

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✦ Synopsis

Antibody-dependent cell-mediated cytotoxicity (ADCC) exhibited by peripheral blood leukocytes was used as a criterion for assessing immune competence of groups of noncancerous individuals and of treated and untreated cancer patients. The results show that, as a group, leukocytes of nontreated cancer patients exhibited significantly lower ADCC than that exhibited by leukocytes of noncancerous individuals. However, the ADCC of leukocytes from cancer patients under treatment approximated that of normals. Thus, using ADCC as criterion, the results indicate that as a group, cancer patients under treatment tend to exhibit restored immune competence.

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