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Antibody, complement and accommodation in ABO-incompatible transplants

✍ Scribed by Karen E King; Daniel S Warren; Milagros Samaniego-Picota; Sally Campbell-Lee; Robert A Montgomery; William M Baldwin III

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
138 KB
Volume
16
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

Many facets of accommodation have been explored since this process was first observed in ABO-incompatible renal allografts over 17 years ago. Intriguing new pieces of the puzzle have emerged to be fitted into the picture in several places. For example, vascular endothelial cells can be stimulated to secrete substantial amounts of blood group A and B antigens linked to von Willebrand factor; the antibody response to A and B antigens stimulated by ABO-incompatible renal allografts can show epitope spreading; complement can inhibit inflammation through actions of some complement split products, particularly iC3b and C3a; endothelial cells can upregulate various cytoprotective mechanisms; and clinically, new protocols for achieving accommodation have been implemented with improved results.

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