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Antibody against a novel, myriocin (ISP-I)-Based immunosuppressant, FTY720

✍ Scribed by Tetsuro Fujita; Norimasa Matsumoto; Shuji Uchida; Takeyuki Kohno; Takaaki Shimizu; Ryoji Hirose; Kazuo Yanada; Wasako Kurio; Kazuhito Watabe


Book ID
104364977
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
156 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis


AbstractÐAn antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody reacted to not only AMPD-4, but also FTY720, it should be useful for immunoassay of FTY720 in body ¯uids, tissues and cells.