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Antibodies to the second Epstein-Barr virus nuclear antigen in non-Hodgkin lymphomas

✍ Scribed by L. Gergely; J. Czeglédy; L. Váczi; K. Pálóczi; G. Szegedi

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
227 KB
Volume
176
Category
Article
ISSN
0300-8584

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✦ Synopsis

Human antibodies against the first and second Epstein-Barr virus encoded nuclear antigens (EBNA-1 and EBNA-2) were analysed by modified ELISA reaction on immunoblots: 5 out of 20 EBNA-1 positive, healthy donor sera reacted with the EBNA-2. Healthy EBV seronegatives contained no antibodies against EBNA-2. The antibodies against this EBNA-2 developed several months after acute EBV infections. Four out of 8 infectious mononucleosis sera failed to react EBNA-2 in the late stage. In the group of EBV seropositire patients with non-Hodgkin lymphoma, 14 out of 18 sera contained EBNA-2 antibodies.

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