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Antibodies to Saccharomyces cerevisiae (ASCA) are associated with fistulizing and fibrostenotic ileal Crohn's disease (CD), but not NOD2 genetype

โœ Scribed by Themistocles Dassopoulos; Marcia Cruz-Correa; Monica Talor; Franklin J. Nouvet; Amir Karban; Theodore Bayless; C. Lynne Burek; Steven Brant


Book ID
119426875
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
187 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Background: Both antibodies to saccharomyces cerevisiae (asca) and carriage of two mutated nod2/card15 alleles are associated with ileal crohn's disease (cd) and complications requiring bowel surgery. we assessed the asca titer as a marker of cd clinical behavior. ## Methods: In a cross-sectio

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Background: Antibodies directed against Saccharomyces cerevisiae (ASCA), perinuclear components of neutrophils (pANCA), and porin protein C of Escherichia coli (anti-OmpC) are reported to be associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Si