Antibodies to histone (h2a–h2b)–dna complexes in the absence of antibodies to double-stranded dna or to (h2a–h2b) complexes are more sensitive and specific for scleroderma-related disorders than for lupus
✍ Scribed by Daniel J. Wallace; Hun-Chi Lin; Guo Qiu Shen; James B. Peter
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 270 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Objective:
To assess the role of antibodies to histones h2a, h2b, and anti-double-stranded dna which form (h2a-h2b)-dna complexes in patients with scleroderma-related disorders.
Methods:
Antihistone antibodies were measured, by enzyme immunoassay, in 26 patients with scleroderma-related disorders, 100 patients with systemic lupus erythematosus (sle), and 24 patients with rheumatoid arthritis.
Results:
Antibodies to histone (h2a-h2b)-dna complex were more commonly seen in patients with scleroderma-related disorders than in those with sle (p < 0.0001).
Conclusion:
Scleroderma-related disorders should be included among conditions in which various types of antihistone antibodies are produced. a hypothesis to account for this finding is discussed.