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Antibodies specific for the carboxy-terminal region of the major surface glycoprotein of simian rotavirus (SA11) and human rotavirus (Wa)

✍ Scribed by Hans-Jürgen Streckert; Barbara Grunert; Hermann Werchau


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
445 KB
Volume
30
Category
Article
ISSN
0730-2312

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✦ Synopsis


Antibodies specific for the major outer capsid protein (VP7) of the simian rotavirus SAll were obtained by immunization of rabbits with a synthetic peptide, Ser-Ala-Ala-Phe-Tyr-Tyr-Arg-Val, corresponding to the eight carboxy-terminal amino acids of the viral protein predicted from the nucleotide sequence of the gene segment 9 of the SAll genome. As the carboxy-terminal region of the VP7 of human rotavirus Wa has an identical sequence, cross-reactivity of the raised antibodies was observed with this strain.