Antibodies directed at mouse IL-2-R α and β chains act in synergy to abolish T-cell proliferation in vitro and delayed type hypersensitivity reaction in vivo

Antibodies directed at mouse IL-2-R α an

Antibodies directed at mouse IL-2-R α andβchains act in synergy to abolish T-cell proliferation in vitro and delayed type hypersensitivity reaction in vivo

✍ Christine François; Jacques Dantal; Michel Sorel; Michel Cherel; Masayuki Miyasa 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 570 KB

The anti-mouse IL-2-R beta chain mAb TM-beta 1 which, by itself, does not affect IL-2-dependent proliferation through the high affinity mouse IL-2 receptor, was shown to cooperate in a synergistic way with a set of anti-IL-2-R alpha chain mAbs both in vitro and in vivo. In vitro, when associated at