Antibodies against heart tissue in transplantation of xenogeneic aortic valves

First quantitative assay of alpha-Gal in

First quantitative assay of alpha-Gal in soft tissues: Presence and distribution of the epitope before and after cell removal from xenogeneic heart valves

✍ F. Naso; A. Gandaglia; L. Iop; M. Spina; G. Gerosa 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 1002 KB

Decellularized xenograft heart valves might be the ideal scaffolds for tissue engineered heart valves as the alternative to the currently used biological and mechanical prostheses. However, removal of the alpha-Gal epitope is a prerequisite to avoid hyperacute rejection of untreated xenograft materi