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Antibiotically Active Amino-Acid Copolymers related to Gramicidin S

✍ Scribed by KATCHALSKI, EPHRAIM; BERGER, ARIEH; BICHOWSKY-SLOMNICKI, LEAH; KURTZ, JOSEPH

Book ID
109585342
Publisher
Nature Publishing Group
Year
1955
Tongue
English
Weight
211 KB
Volume
176
Category
Article
ISSN
0028-0836

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An Adamantyl Amino Acid Containing Grami
An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity
✍ Dr. Varsha V. Kapoerchan; Dr. Annemiek D. Knijnenburg; Miquel Niamat; Emile Spal πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 437 KB

## Abstract The cyclic cationic antimicrobial peptide gramicidinβ€…S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or four positive charges and characteristics ranging