Antibacterial properties of nitric oxide-releasing sol-gels

✍ Scribed by Nablo, Brian J. ;Schoenfisch, Mark H.

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 365 KB
• Volume: 67A
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.a.20030

✦ Synopsis

Abstract

The antibacterial characteristics of nitric oxide (NO)‐releasing sol‐gel coatings are described. The NO release from these surfaces is steady over short periods (≈1 h) and measurable over several days. The ability of NO to prevent bacterial adhesion is evaluated by exposing controls and NO‐releasing sol‐gels to ≈10^8^ colony‐forming units (cfu)/mL saline suspensions of Pseudomonas aeruginosa. Pseudomonas aeruginosa adhesion to sol‐gel controls varies depending on the sol‐gel formulation. Sol‐gel surfaces capable of NO release decrease bacterial adhesion by 30% to 95% relative to controls. The contact angle measurements of control and NO‐releasing surfaces are similar, supporting NO's action as an antibacterial agent against bacterial adhesion. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 1276–1283, 2003