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Antibacterial lysine analogs that target lysine riboswitches

โœ Scribed by Sudarsan, Narasimhan; Breaker, Ronald R; Blount, Kenneth F; Wang, Joy Xin; Lim, Jinsoo


Book ID
109914126
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
345 KB
Volume
3
Category
Article
ISSN
1552-4450

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Poly-L-lysine (PLL), a homopolymer of amino acid L-lysine (LL), has been frequently used for drug delivery. Here, we report that PLL is an effective agent to inhibit propagation of prions that cause fatal and incurable neurologic disorders in humans and animals, termed prion diseases. In our recent