Antibacterial efficacy of new commercially manufactured disinfectant substances against Salmonella typhimurium
✍ Scribed by Dr. Viktor Majtán; L'Ubica Majtánová
- Book ID
- 102391669
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 276 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0233-111X
No coin nor oath required. For personal study only.
✦ Synopsis
The antibacterial effect of 19 new commercially manufactured disinfectant substances on a Salmonella typhimuriurn strain was studied. The substances tested represent 9 quaternary ammonium salts (QAT) and 11 combinated QAT with other ingredients. The antimicrobial efficacy was characterized by influencing the growth and reproduction of bacterial cells expressed either by MIC and ED,, values (ED,, values represent concentration of substance in pg/ml which cause inhibition of growth by 50%), as well as by the inhibition of incorporation rate of ["C] adenine and ["C] leucine. The disinfectants are divided into three groups according to their efficacy. The first group comprises substances with strong inhibitory effect (MIC 0.04-0.19 pg/ml) such as Neoquat S , Antibacteric P, Divoquat forte, Sokrena and Diesin forte (sole from the group belonging to multicomponent substances). QATexcept Antibacteric Pinterfere with energy metabolism (R values ~1 ) .
The second group represents substances with good antibacterial efficacy (MIC values up 1.56 pg/ml), and the third group substances with MIC values up 12.5 pg/ml. Cutasept G was found ineffective also in the concentration 100 pg/ml. The method of inhibition of [I4C] precursors is suitable as one from possible criterion in evaluation of antibacterial efficacy of various synthetic substances.