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Antiarrhythmic and electrophysiological effects of SD-3212, a novel Na+and Ca++channel blocker, in anaesthetized dogs with myocardial infarction in comparison with its stereoisomer (SD-3211) and bepridil

โœ Scribed by S. Nagashima; T. Uematsu; S. Araki; T. Matsuzaki; M. Fukuchi; H. Hashimoto; M. Nakashima


Book ID
112274721
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
920 KB
Volume
345
Category
Article
ISSN
0028-1298

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Antiarrhythmic effects of a novel Na+ an
โœ Nobuaki Miyawaki; Fumiko Yamazaki; Tatsuji Furuta; Tatsuro Shigei; Hideyasu Yama ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 382 KB

The electrophysiological and antiarrhythmic effects of a structurally novel compound, SD-3212, were evaluated in comparison with its enantiomer (SD-3211). In isolated guinea pig ventricular muscles, SD-3212 reduced the maximum upstroke velocity and the plateau phase of action potential in a concentr