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Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer

✍ Scribed by Wu, Y.; Zhong, Z.; Huber, J.; Bassi, R.; Finnerty, B.; Corcoran, E.; Li, H.; Navarro, E.; Balderes, P.; Jimenez, X.; Koo, H.; Mangalampalli, V. R.M.; Ludwig, D. L.; Tonra, J. R.; Hicklin, D. J.


Book ID
125488190
Publisher
American Association for Cancer Research
Year
2006
Tongue
English
Weight
642 KB
Volume
12
Category
Article
ISSN
1078-0432

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## Abstract The human vascular endothelial growth factor receptor‐1 (VEGFR‐1, or Flt‐1) is widely expressed in normal and pathologic tissue and contributes to the pathogenesis of both neoplastic and inflammatory diseases. In human cancer, VEGFR‐1 mediated signaling is responsible for both direct tu