D-aspartic acid 8-hydroxamate (DAH), an aspartic acid analogue, exerts anti-tumoral activity against murine leukemia L5178Y both in vitro and in vivo. We show here that DAH displays activity against Friend leukemia cells (FLC) in vitro: a concentration of 2 mM results in a total inhibition of cell g
Anti-tumoral activity of L and D isomers of aspartic acid β-hydroxamate on L5178Y leukemia
✍ Scribed by Nicole Thomasset; Farid Hamedi-Sangsari; Roselyne Tournaire; Claudine Navarro; Serge Malley; Liliane Goetsch; Jacques Grange; Jorge Vila
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 463 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Death before the time of death of untreated controls.-'Increased life s an see "Material and Meth0ds."-~3 times daily at 8-hr inter~aIs.-~Twice daig a: 12-hr interval.-'Once a day.
📜 SIMILAR VOLUMES
## Abstract A glutamine analogue, L‐glutamic acid γ‐monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti‐tumoral activity __in vivo__ against L1210 leukemia and B16 melanoma. __In vitro__, GAH caused concentration‐dependent inhibition of L1210 cell
The antileukemic and anti-HTLV-I11 (anti-HIV) agent avarol, a sesquiterpenoid hydroquinone, was determined to be converted into its corresponding quinone derivative avarone via the semiquinone free radical. Its g-value was 2.0047; after hyperfine splitting the energy levels revealed 16 isotropic Hfs