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Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer’s Aβ Peptide

✍ Scribed by Daniel Paris; Nikunj Patel; Nowell J. Ganey; Vincent Laporte; Amita Quadros; Michael J. Mullan


Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
514 KB
Volume
16
Category
Article
ISSN
1573-3149

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## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state