๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Anti-tumor potential of retinoic acid: Stimulation of immune mediated effectors

โœ Scribed by Paul Q. Patek; John Leslie Collins; Ganesa Yogeeswaran; Gunther Dennert

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
426 KB
Volume
24
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Data are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A ร— TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymusโ€dependent immuneโ€mediated effectors able to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition.

๐Ÿ“œ SIMILAR VOLUMES

Serum-mediated blocking of cell-mediated
Serum-mediated blocking of cell-mediated anti-tumor immunity in a melanoma patient: Association with BCG immunotherapy and clinical deterioration
โœ Nelson L. Levy; M. S. Mahaley Jr.; Eugene D. Day ๐Ÿ“‚ Article ๐Ÿ“… 1972 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 318 KB ๐Ÿ‘ 1 views

## Abstract A patient with melanoma was found to have lymphocytes highly cytotoxic for autogenous tumor cells but not for fibroblasts. Autogenous serum did not block the cytotoxicity. He then received an injection of BCG into a small tumor nodule. Three weeks later, in association with accelerated

Tumor bound immunoglobulins: The relatio
Tumor bound immunoglobulins: The relationship between the in vivo coating of tumor cells by potentially cytotoxic anti-tumor antibodies, and the expression of immune complex receptors
โœ Gary Braslawsky; Maya Ran; Isaac P. Witz ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 497 KB

## Abstract In this study we investigated the relationship between binding of antiโ€tumor antibodies by polyomaโ€virusโ€induced SEYFโ€a tumor cells and the expression of immuneโ€complex receptors on these cells. It was shown that in vivo propagated cells became progressively coated with IgG. The increas

Stimulation of DNA synthesis by tumor pr
Stimulation of DNA synthesis by tumor promoters in primary rat hepatocytes is not mediated by arachidonic acid metabolites
โœ Chow H. Lee; Anthony M. Edwards ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 206 KB

Studies in vivo using inhibitors of eicosanoid synthesis suggested that prostaglandins may play a role in mediating tumor promotion in liver by agents such as phenobarbital (PB). However, it is not clear whether any stimulation of arachidonic acid metabolism/prostaglandin formation results directly

NKG2D engagement of colorectal cancer-sp
NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity
โœ Cristina Maccalli; Daniela Pende; Chiara Castelli; Maria Cristina Mingari; Paulโ€„ ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 333 KB

The NKG2D receptor is expressed by human NK, gammadelta T and alpha/beta T lymphocytes and its engagement results in the stimulation of effector cells. We evaluated the role of NKG2D receptor in anti-colorectal cancer (CRC) immune response. The cell surface expression of stress-inducible NKG2D ligan