Anti-Tumor-Initiating Effects of Monascin, an Azaphilonoid Pigment from the Extract of Monascus pilosus Fermented Rice (Red-Mold Rice)
✍ Scribed by Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Ayaka Kiyota; Ken Yasukawa; Naoyuki Sakamoto; Yumiko Kimura; Takashi Suzuki; Junko Takayasu; Hoyoku Nishino
- Book ID
- 101769462
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 76 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1612-1872
No coin nor oath required. For personal study only.
✦ Synopsis
Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO À ; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN-and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.