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Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retroviral or adenoviral gene transfer

โœ Scribed by Thomas Felzmann; William J. Ramsey; R.Michael Blaese


Book ID
117469253
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
387 KB
Volume
135
Category
Article
ISSN
0304-3835

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We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects