𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Anti-tumor antibodies in normal mouse sera

✍ Scribed by Sue Ellen Martin; W. John Martin

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
536 KB
Volume
15
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Evidence for the involvement of the immune system in surveillance against nascent tumors was sought by testing whether normal mouse sera were cytotoxic in the presence of rabbit complement for a variety of lymphoid and non‐lymphoid tumor‐cell lines. Tumor‐reactive antibodies were detected in all mouse sera tested, including sera from congenitally athymic (nude) mice. Considerable variation was noted, however, in the levels of naturally occurring antibodies against specific tumors. Anti‐tumor antibodies were identified as being predominantly IgM. The possible relevance of natural anti‐tumor antibodies to immune surveillance was discussed.

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## Abstract IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzyme‐linked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy agematched controls. Significantly greater binding (p<0.01) was found in breast‐cancer‐