✦ LIBER ✦

Anti-tumor activity of ceramides and glycosphingolipids in a murine tumor system

✍ Scribed by Morimasa Maru; Muneo Haraguchi; Hideyoshi Higashi; Shiro Kato; Takashi Kurimura; Masaharu Naiki; Nobutaka Wakamiya

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 689 KB
Volume: 53
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910530420

No coin nor oath required. For personal study only.

✦ Synopsis

The anti-tumor activity of 7 sphingolipids, 2 ceramides and 5 glycosphingolipids against the syngeneic murine ascitic tumors MH I34 and MM 102 in C3H mice was examined. Five of these compounds showed anti-tumor activity against the tumors, ceramide type-IV (Cer-lv) having the highest activity without cytotoxic or cytostatic activity. These results indicate that the fatty acid in ceramide and sugar chains binding to it affect the anti-tumor activity in vivo. The anti-tumor activity of Cer-IV depended on the time of treatment. Mice treated with Cer-IV one day after tumor implantation showed the highest rate of survival. The cured mice were resistant to rechallenge with the same tumor (MH 134 + MH 134, MM 102 + MM 102) but not with a heterologous tumor (MH I34 -+ X5563, MM I02 + X5563), indicating that the effect of Cer-IV may be due to in vivo induction of specific immunity. Studies with various antibodies demonstrated that the anti-tumor effect of Cer-IV was inhibited by all the antibodies tested (L3T4, Lyt-2, and Thy-1.2 T cells, macrophages, and TNFu) in the induction phase (before Cer-IV administration) and by the antibodies of L3T4 and TNFu in the effector phase (after Cer-IV administration). Therefore, the anti-tumor effect of Cer-IV in this system depended on the host immune response rather than on its direct cytotoxic and/or cytostatic action.

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