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Anti-tumor activity of a 3-oxo derivative of oleanolic acid

✍ Scribed by Dan Huang; Yan Ding; Yan Li; Wenming Zhang; Weishuo Fang; Xiaoguang Chen

Book ID: 116333702
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 268 KB
Volume: 233
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2005.03.019

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## Abstract Oleanolic acid (OA), a pentacyclic triterpenoid exhibits potent anti‐tumor activity against many tumor cell lines. But the mechanisms through which OA inhibits osteosarcoma cells are not known. The mammalian target of rapamycin (mTOR) serves as a central regulator of cell growth, prolif