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Anti-TGF-β Antibody Combined with Dendritic Cells Produce Antitumor Effects in Osteosarcoma

✍ Scribed by Masanori Kawano MD, PhD, Ichiro Itonaga MD, PhD, Tatsuya Iwasaki MD, Hiroyuki Tsuchiya MD, PhD, Hiroshi Tsumura MD, PhD


Book ID
113092362
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
460 KB
Volume
470
Category
Article
ISSN
0009-921X

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## Abstract Dendritic cells (DC) are potent antigen‐presenting cells that can present tumor antigens chaperoned by heat shock proteins (HSPs), while local hyperthermia (LHT) can increase the expression of HSPs. In this study, we determine if intratumoral injection of immature DC after LHT (LHT+IT‐D