Anti-ss-a antibody and other antinuclear antibodies in systemic lupus erythematosus
β Scribed by Eve Scopelitis; Joseph J. Biundo Jr.; Margaret A. Alspaugh
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 653 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0004-3591
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β¦ Synopsis
Abstract
Randomly selected sera from 88 patients with systemic lupus erythematosus (SLE) were studied for the frequency of antibodies to SSβA, SSβB, RANA, RNP, Sm, Scβ1, and dsDNA. Results were in agreement with previous reports except for an increased incidence of antiβSSβA antibody (33%). Nine of 14 patients with antiβSSβA antibody on whom serial studies were performed had fluctuating titers. Titer changes often correlated with disease activity and dsDNA antibody levels.
π SIMILAR VOLUMES
Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a