## Abstract Glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are the two key incretin hormones released from the gastrointestinal tract that regulate blood glucose homeostasis through potent insulin secretion. The rapid degradation of GIP and GLP‐1 by the ubiqu
✦ LIBER ✦
Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice
✍ Scribed by Lee, Eun Young; Kim, Yeon Wook; Oh, Hyunhee; Choi, Cheol Soo; Ahn, Jin Hee; Lee, Byung-Wan; Kang, Eun Seok; Cha, Bong Soo; Lee, Hyun Chul
- Book ID
- 122159756
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 542 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1532-8600
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## Abstract ## Background The two major incretin hormones, glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are being actively explored as anti‐diabetic agents because they lower blood glucose through multiple mechanisms. The rapid inactivation of GIP and GLP‐
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