Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus
β Scribed by S. N. Wong; V. Shah; M. J. Dillon
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 271 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0340-6997
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π SIMILAR VOLUMES
Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.